Oklahoma owns the series with Iowa State in college football, winning the last 17 meetings straight up and going 9-2 against the spread over the last 11 encounters. The Sooners shoot to extend that dominance and stay unbeaten in Big 12 play when they battle the Cyclones on Thursday night in Ames.

Point spread: The Sooners opened as 19.5-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)

College football pick, via Odds Shark computer: 47.4-19.8 Sooners Bleacher Report - College Football
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