Ohio State ran its road winning streak to 20 games, going 13-7 against the spread in the process, with last week's overtime victory at Wisconsin. The Buckeyes will shoot for No. 21 in a row on the road when they hit Happy Valley to take on the Penn State Nittany Lions on Saturday night.

Point spread: The Buckeyes opened as 20-point favorites, according to sportsbooks monitored by Odds Shark (line updates and matchup report).

College football pick, via Odds Shark computer: 45.8-15.6 Buckeyes Bleacher Report - College Football
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