Louisville covered three touchdowns last week but larger spreads had been cutting into the Cardinals' profits, forcing a recent 0-2-1 slide against the numbers. Louisville goes against another big number when it visits Virginia on Saturday afternoon in Charlottesville.

Point spread: The Cardinals opened as 27-point favorites, according to sportsbooks monitored by Odds Shark. Line updates and matchup report.

College football pick, via Odds Shark computer: 52.0-17.8 Cardinals Bleacher Report - College Football
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