Louisville is 5-1 straight up in its last six meetings with Syracuse—4-2 against the spread—stretching back to their days as Big East rivals. Coming off a huge offensive performance, the Cardinals will be big favorites for Friday night's meeting with the Orange at the Carrier Dome.

Point spread: Cardinals opened as 13-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)

College football pick, via Odds Shark computer: 33.8-8.4 Cardinals (
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