Clemson is 2-0 against Louisville in the two meetings since the latter joined the ACC but 0-2 against the spread, as the Cardinals have given the Tigers two tough games.

Bettors might expect more of the same when the teams meet for a huge conference showdown—with national championship implications to boot—on Saturday night at Death Valley.

Point spread: The Tigers opened as 3.5-point favorites, according to Bleacher Report - College Football
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