Florida State won three in a row in the rivalry with Clemson from 2012-14, but the Tigers beat the Seminoles last year and are 6-5 straight up and 8-3 against the spread over the last 11 meetings. In a big game down in the ACC, national-title-contending Clemson clashes with Florida State on Saturday night down in Tallahassee.

Point spread: The Tigers opened as three-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)

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