Clemson is 3-0 straight up against Syracuse since the latter joined the ACC as part of the changing college football landscape a few seasons ago. But the Orange are 2-1 against the spread during that span, covering twice as large underdogs. Syracuse once again will be the recipient of a bunch of points when it tussles with the Tigers on Saturday.

Point spread: The Tigers opened as 28.5-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)

College football pick, via Odds Shark...

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