Louisville exploded out of the gate this season with three straight wins and covers, but as word got out, the lines got tougher, and the Cardinals are 0-2-1 against the spread the last three weeks. North Carolina State, meanwhile, playing under the radar, is 4-0 ATS over its last four games. Both teams will try to avoid a second ACC defeat when they meet Saturday afternoon at Papa John's Cardinal Stadium.

Point spread: The Cardinals opened as 20-point favorites, according to sportsbooks monitored by Odds Shark. Bleacher Report - College Football
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