After notching three straight wins in nonconference action, the fourth-ranked Michigan Wolverines will open Big Ten play at home against the Penn State Nittany Lions on Saturday.

Penn State enters the matchup at 2-1, most recently recording a victory over Temple. The Nittany Lions will attempt to break a two-game slide in the series with the Wolverines.

In Week 3, Michigan fell two touchdowns behind Colorado. However, once the defense settled in, Jim Harbaugh's team rattled off 38 of the next 45 points and cruised late to keep its record unblemished.

ABC will broadcast the clash at 3:30 p.m. ET. Michigan opened as a 16.5-point favorite, according to Odds Shark.